Fig. 3

Comparison of in vitro siRNA release profile from siRNA encapsulated anti-NTSR1-mAb functionalized and non-functionalized nanoparticles at pH 5 and 7. siRNA was more efficiently released at pH 5 due to the superior solubility of human IgG at that pH. Functionalization of the nanoparticles did not seem to affect the release rate at each of the pH values. n = 3 for each sample point