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Table 1 The effects of variable parametes on particle size, PDI, zeta potential, encapsulation efficiency and loading capacity of nanoparticles (Mean ± SD, n = 3)

From: Novel targeted siRNA-loaded hybrid nanoparticles: preparation, characterization and in vitro evaluation

Nanoparticle batch

Particle size (NM)

PDI

Zeta potential (mV)

Encapsulation efficiency (%)

Loading capacity (%)

IP-1

672.4 ± 17.9

0.08 ± 0.02

+17.1 ± 0.8

41.1 ± 0.2

0.71 ± 0.02

IP-2

424.6 ± 12.4

0.04 ± 0.01

+17.3 ± 0.4

50.2 ± 0.4

1.23 ± 0.03

IP-3

135.4 ± 5.4

0.07 ± 0.03

+16.7 ± 0.2

60 ± 0.4

2.04 ± 0.06

IP3-anti-NTSR1-mAb

140.2 ± 2.4

0.2 ± 0.04

0.0 ± 0.3

N/A

N/A

IP-4

716.1 ± 15.2

0.1 ± 0.04

+17.4 ± 0.4

35.4 ± 0.4

0.62 ± 0.04

IP-5

545.3 ± 14.3

0.06 ± 0.03

+17.9 ± 0.3

40.3 ± 0.3

0.81 ± 0.03

IP-6

389.2 ± 11.4

0.06 ± 0.05

+17.5 ± 0.4

48.5 ± 0.5

1.21 ± 0.05

IP-7

820.5 ± 12.4

0.08 ± 0.03

+17.4 ± 0.5

30.3 ± 0.1

0.53 ± 0.02

IP-8

799.3 ± 11.4

0.1 ± 0.04

+16.9 ± 0.6

37.3 ± 0.3

0.65 ± 0.03

IP-9

589.3 ± 10.4

0.09 ± 0.05

+17.2 ± 0.3

42.6 ± 0.4

0.82 ± 0.04

  1. PDI polydispersity index