Table 5 Variable parameters used in the formulation of different nanoparticle batches
Nanoparticle batch | Concentration of human IgG (mg/mL) | Concentration of poloxamer-188 (%w/v) | Magnetic stirring rate (rpm) | Amount of siRNA (µg) |
|---|---|---|---|---|
IP-1 | 5 | 0.2 | 125 | 187 |
IP-2 | 5 | 0.2 | 250 | 187 |
IP-3 | 5 | 0.2 | 350 | 187 |
IP-4 | 7.5 | 0.2 | 125 | 187 |
IP-5 | 7.5 | 0.2 | 250 | 187 |
IP-6 | 7.5 | 0.2 | 350 | 187 |
IP-7 | 10 | 0.2 | 125 | 187 |
IP-8 | 10 | 0.2 | 250 | 187 |
IP-9 | 10 | 0.2 | 350 | 187 |