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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Human mesenchymal stem cells labelled with dye-loaded amorphous silica nanoparticles: long-term biosafety, stemness preservation and traceability in the beating heart

Fig. 5

Imaging of SiO2-NPs -labelled hMSCs in normally perfused rat hearts. a Reconstruction of a 10 µm transverse slice (juxtaposition of consequent stacks of 5× magnification) to show the localization of labelled hMSCs in normal ventricles. White points: clusters of hMSCs. Red line: perimeter of cell distribution inside normal ventricles. b Subset showing spare distribution of labelled hMSCs (red) inside cardiac tissue. Magnification 5×, scale bar 200 µm. c Representative confocal reconstruction with superposition of bright field, hMSCs (red) and nuclei (blue). The white dotted line limits the perimeter of the volume illustration showed in (d), where arrowheads stress the co-localization between labelled hMSCs (red) and nuclei (blue)

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