Fig. 6
Imaging of SiO2-NPs -labelled hMSCs inside infarcted hearts. a Reconstruction of a 10 µm transverse slice to show the distribution of labelled hMSCs in infarcted hearts. White points: clusters of hMSCs. Red line: perimeter of cell distribution inside infarcted ventricles. b Subset illustrating labelled hMSCs (red) clustered inside ventricular tissue. Magnification 5×, scale bar 200 µm. c Representative confocal reconstruction with superposition of bright field, hMSCs (red) and nuclei (blue). The white dotted line is the perimeter of the volume representation in (d) to underline the higher co-localization between labelled hMSCs (red) and nuclei (blue) due to major cell aggregation typical of the injured area. Magnification 40×, scale bar 50 µm