Fig. 6
From: Reduced graphene oxide induces transient blood–brain barrier opening: an in vivo study
Electron micrographs of rat hippocampal capillaries. a Control showing the electron-opaque extracellular tracer (lanthanum nitrate) confined to the capillary lumen. b Capillary 1 h and c 3 h following rGO administration. Note that lanthanum nitrate lining the luminal inner surface is leaking through the inter-endothelial contact (black boxes). Insets show higher magnification of the contacts. Ax axon, E endothelial cell, m mitochondria, P pericyte; asterisk: lumen; double asterisk, Dashed line delineates regions of cytotoxic edema in perivascular astrocytes. Bars 2 μm (a, c), 1 μm (b, inset c), 200 nm (inset b)