Fig. 4

TEM images of laser-irradiated cells containing endosomes with CPP-AuNPs. Cells irradiated with 25 mJ/cm\(^{2}\) (a) and 35 mJ/cm\(^{2}\) (b, c). CPP-AuNPs are desagglomerated and endsosomes are partly or completely opened. Most particles are isolated, but still close to each other and the endosome they escaped (red dashed arrows). Some particles are distributed already inside the cytoplasm (red dashed circles). Blue arrows indicate laser-induced vacuoles. Vacuoles are also found in mitochondria (green dotted arrows) and blown up lumen of the endoplasmic reticulum (yellow arrows). Scale bars: a 500 nm, b 300 nm, inset 100 nm, c 800 nm