Table 2 Acute toxicity of DS-PPF-NPs in different concentration (control, 3, 6, 12.5 and 100 mg/kg equivalent of disulfiram) on hematological markers in mice
Parameter | Groups | ||||
|---|---|---|---|---|---|
Control | DS-PPF-NPs (3 mg/kg) | DS-PPF-NPs (6 mg/kg) | DS-PPF-NPs (12.5 mg/kg) | DS-PPF-NPs (100 mg/kg) | |
Animal weight (g) | 22.3 ± 1.9 | 22.7 ± 3.6 | 21.4 ± 2.2 | 22.9 ± 2.4 | 23.2 ± 1.8 |
Urea (mg/dL) | 63.3 ± 7.6 | 75.0 ± 0.0 | 63.3 ± 10.4 | 65.0 ± 8.7 | 64.7 ± 6.5 |
Cr (mg/dL) | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.1 | 0.5 ± 0.1 |
ALP (U/L) | 571.7 ± 92.9 | 478.3 ± 100.5 | 470.0 ± 111.7 | 583.0 ± 91.2 | 262.0 ± 39.3 * |
SGOT (U/L) | 396.7 ± 177.9 | 410.0 ± 91.7 | 293.3 ± 7.6 | 396.0 ± 152.7 * | 75.0 ± 6.0 * |
SGPT (U/L) | 41.7 ± 18.9 | 63.3 ± 15.3 | 53.3 ± 10.4 | 65.0 ± 5.0 | 85.0 ± 6.2 * |
D. BIL (mg/dL) | 0.5 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.0 | 0.4 ± 0.0 | 0.2 ± 0.0 * |
ALB (mg/dL) | 2.5 ± 0.0 | 3.3 ± 0.6 | 3.0 ± 0.5 | 5.0 ± 0.0 * | 4.7 ± 0.6 * |
Total protein (mg/dL) | 4.8 ± 0.6 | 4.5 ± 0.0 | 4.2 ± 1.5 | 7.3 ± 0.2 * | 6.6 ± 0.3 * |
Glucose (mg/dL) | 208.3 ± 70.8 | 271.7 ± 102.1 | 265.0 ± 98.4 | 243.0 ± 20.8 | 183.0 ± 35.1 |
WBC (1000/mm3) | 12.8 ± 3.6 | 11.2 ± 0.8 | 12.3 ± 0.9 | 5.4 ± 0.7 * | 3.6 ± 0.2 * |
RBC (Millin/mm3) | 9.5 ± 0.3 | 8.7 ± 0.5 | 8.3 ± 0.5 | 8.7 ± 0.2 | 9.5 ± 0.8 |
HGB (mg/dL) | 15.2 ± 0.1 | 13.9 ± 0.7 | 13.0 ± 0.9 | 13.2 ± 0.8 | 14.4 ± 1.3 |
HCT (%) | 42.5 ± 0.8 | 44.9 ± 2.3 | 44.1 ± 2.8 | 37.2 ± 2.4 | 39.7 ± 2.8 |
MCV (FL) | 44.6 ± 0.5 | 52.0 ± 0.5 | 53.3 ± 0.3 | 42.8 ± 2.0 | 42.0 ± 1.6 |
MCHC (mol/L) | 31.7 ± 0.3 | 30.9 ± 0.5 | 30.5 ± 0.2 | 15.2 ± 0.6* | 15.2 ± 0.5* |
Plt (1000/mm3) | 1114.0 ± 77.8 | 744.0 ± 127.8 | 816.3 ± 71.6 | 1028.7 ± 124.4 * | 880.7 ± 55.2 * |