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Table 3 Effect of drug treatments on cell aspect ratio (R) of different substrates

From: Contribution of actin filaments and microtubules to cell elongation and alignment depends on the grating depth of microgratings

Drug treatment

Cell aspect ratio (R)a

Drug

Concentration (µm)

Flatb

FN-lines (1 µm line)

1 µm grating (0.35 µm deep)

1 µm grating (1 µm deep)

None

 

2.5 ± 0.7 (n = 153)

5.0 ± 1.3 (n = 141)

4.8 ± 1.3 (n = 111)

6.3 ± 1.5 (n = 123)

CD

0.1

2.2 ± 0.8 (n = 124)

3.8 ± 1.3 (n = 148)

3.5 ± 1.3 (n = 101)

6.1 ± 1.9 (n = 156)

0.5

2.1 ± 0.6 (n = 149)

3.3 ± 1.1 (n = 154)

3.0 ± 1.2 (n = 104)

5.9 ± 1.8 (n = 162)

1

2.0 ± 0.7 (n = 155)

2.8 ± 0.9 (n = 131)

3.0 ± 1.1 (n = 105)

9.1 ± 2.8 (n = 182)

Noc

0.04

1.7 ± 0.5 (n = 149)

1.8 ± 0.6 (n = 102)

3.5 ± 1.0 (n = 123)

5.9 ± 1.3 (n = 112)

1

1.5 ± 0.4 (n = 112)

1.5 ± 0.4 (n = 102)

1.8 ± 2.1 (n = 102)

1.7 ± 0.4 (n = 110)

  1. aR was determined by measuring cell length (L) and cell width (W) at 12 h after seeding. L is defined as the length of the long axis of the cell, while W is defined as the maximum width of a cell axis that is perpendicular to the long axis
  2. bFlat surface: TCPS coated with FN
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Journal of Nanobiotechnology

ISSN: 1477-3155

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