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Table 1 Oral repeated dose toxicity studies with amorphous silica yielding liver effects

From: Critical review of the safety assessment of nano-structured silica additives in food

Species Study length Effect LOAEL NOAEL Reference
Wistar rats 5–8 weeks Liver atrophy 1000 mg/kg body weight per day 500 mg/kg body weight per day [29, 30]
Balb/c mice 10 weeks Fatty liver 1500 mg/kg body weight per day NA [31]
Sprague–Dawley rats 12 weeks Periportal liver fibrosis 810 mg/kg body weight per day NA [32]
Fischer rats 103 weeks Reduced liver weight 1000 mg/kg body weight per day 500 mg/kg body weight per day [33]
  1. Delivery of particles was by inclusion into the feed. This table proposes LOAEL (lowest observed adverse effect level) and NOAEL (no observed adverse effect level) values that differ from those purported in previous risk assessment reports. Other oral repeated dose studies [2527] did not elicit adverse effects