Critical review of the safety assessment of nano-structured silica additives in food

Table 2 Outline of the chronic toxicity study with SAS particles carried out in rats

	Weeks of feeding
	0	5	15	30	50	81	103
Body weight (g)	108 ± 6	174 ± 9	223 ± 11	253 ± 10	310 ± 18	364 ± 26	359 ± 56
Feed intake (g/day)		11.1 ± 0.4	10.4 ± 0.4	10.2 ± 0.5	11.9 ± 0.8	13.2 ± 0.8	12.7 ± 2.7
SAS intake (g/kg body weight per day)		3.2	2.3	2.0	1.9	1.8	1.8

Summarized data from the oral chronic toxicity study in Fischer rats [33]. This table illustrates the relationship between body weight, feed intake and daily doses in the females of the highest dose group, where the feed was supplemented with 5 % (wt/wt) SAS particles. When corrected for the actual feed intake, the daily dose of SAS particles was between 1.8 and 2.0 g/kg body weight during most of the study period

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