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Table 2 Outline of the chronic toxicity study with SAS particles carried out in rats

From: Critical review of the safety assessment of nano-structured silica additives in food

  Weeks of feeding
0 5 15 30 50 81 103
Body weight (g) 108 ± 6 174 ± 9 223 ± 11 253 ± 10 310 ± 18 364 ± 26 359 ± 56
Feed intake (g/day)   11.1 ± 0.4 10.4 ± 0.4 10.2 ± 0.5 11.9 ± 0.8 13.2 ± 0.8 12.7 ± 2.7
SAS intake (g/kg body weight per day)   3.2 2.3 2.0 1.9 1.8 1.8
  1. Summarized data from the oral chronic toxicity study in Fischer rats [33]. This table illustrates the relationship between body weight, feed intake and daily doses in the females of the highest dose group, where the feed was supplemented with 5 % (wt/wt) SAS particles. When corrected for the actual feed intake, the daily dose of SAS particles was between 1.8 and 2.0 g/kg body weight during most of the study period