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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration

Fig. 1

Synthesis and physico-chemical characterization of siRNA-FNP. a Scheme showing HuR-FNP preparation. b TEM image of NP, HuR-NP, and HuR-FNP. Scale bar denotes 100 nm. c Agarose gel electrophoretogram showing siRNA protection by FNP at different time (0, 0.5 and 1 h) points of incubation compared to naked siRNA exposed to serum for 1 h. Free siRNA not exposed to serum was used as internal marker. d siRNA release profile over time from siRNA-FNP in PBS (pH 7.4) measured by Quanti-iT Picogreen Assay (top figure); and from fluorescently labeled siRNA (siGLO)-FNP in acetate buffer (pH 5.5) and in 50 % FBS containing PBS (pH 7.4) [bottom figure]

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