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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration

Fig. 4

Mechanism and specificity of FNP uptake in FRA-expressing H1299 cells. a FNP uptake by H1299 cells, measured by fluorescence intensity of siGLO, was markedly reduced at +4 °C compared to +37 °C. b FNP uptake measured by fluorescence intensity of siGLO was greatly increased in the absence of folic acid in the culture medium at all time-points tested compared to FNP uptake in the medium containing trace amount of folic acid. c Addition of excess of exogenous folic acid (1 mM) to the culture medium reduced the FNP uptake compared to FNP uptake in the medium containing trace amount of folic acid. (error bars denote SD; *p < 0.05; **p < 0.01)

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