Fig. 6
Cellular uptake of TiO2 NPs at single cell level as analyzed by LA-ICP-MS. Depicted are overlapping contour plots of 48Ti with cell morphology of Neuro-2a cells after incubation with TiO2 NPs: 7 nm, 2 μg/mL (a); 7 nm, 10 μg/mL (b); 20 nm, 2 μg/mL (c); and 20 nm, 10 μg/mL (d). Histogram for the cps of TiO2 determined in single cells upon incubation with TiO2 NPs (bin width: 0.02 ng) (e). Histogram of the relative numbers of TiO2 NPs per cell (bin width: 2000 NPs) (f)