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Table 3 Specific features of the different ICP-MS techniques applied in the present study

From: Quantification and visualization of cellular uptake of TiO2 and Ag nanoparticles: comparison of different ICP-MS techniques

Technique

Parameter

Size

Localization

Limitations

Limit of detection (LOD)

ICP-MS

Mass

No

No

Error from NPs attached to culture plates

Ag: 0.05 pg/cell

TiO2: 0.31 pg/cell

SP-ICP-MS

Number

Yes

No

Spherical NPs only, high LODsize for TiO2

Ag: 2.26 × 105 particles (22 nm)a,

TiO2: 1.92 × 105 particles (69 nm)a

LA-ICP-MS

Mass in single cell (relative measure)

No

Yes

Localization for small cells difficult

Ag: 78.5 pg per pippetted spot of 0.5 µl

TiO2: not available in this study

  1. aDiameter of NPs was calculated from LOD