Reduced graphene oxide: nanotoxicological profile in rats

Table 2 rGO effects on hematological parameters of male Wistar rats

Group	Unit	Control	rGO 15 min	rGO 1 h	rGO 3 h	rGO 7 days
RBC	10⁶/μl	7.32 ± 0.09	7.16 ± 0.17	7.45 ± 0.02	7.27 ± 0.11	7.48 ± 0.04
Hb	g/dl	14.27 ± 0.24	13.73 ± 0.12	14.37 ± 0.14	14.00 ± 0.24	14.32 ± 0.37
Hct	%	46.87 ± 0.52	46.13 ± 0.88	48.83 ± 0.57	47.58 ± 0.24	47.70 ± 0.40
MCV	fl	64.00 ± 0.60	64.60 ± 0.23	65.53 ± 1.02	65.44 ± 0.66	63.44 ± 0.49
MCH	pg	19.03 ± 0.23	19.03 ± 0.32	19.27 ± 0.24	19.22 ± 0.21	19.24 ± 0.26
MCHC	g/dl	29.80 ± 0.40	29.57 ± 0.40	29.43 ± 0.08	29.42 ± 0.42	30.38 ± 0.33
PLT	10³/μl	638.3 ± 5.84	650.0 ± 6.92	649.0 ± 10.69	624.2 ± 25.81	636.2 ± 59.19
WBC	10³/μl	7.63 ± 0.60	6.80 ± 1.41*	7.10 ± 0.30	10.83 ± 0.55*^,#	5.03 ± 0.56^#

The same symbol in each column indicates a significant difference between groups
One-way ANOVA, Bonferroni post hoc test; data were shown as mean ± SEM, n = 3–5 in each group
RBC red blood cell; Hb hemoglobin; Hct hematocrit; MCV mean corpuscular volume; MCH mean corpuscular hemoglobin; MCHC mean corpuscular hemoglobin concentration; PLT platelet; WBC white blood cell
*p < 0.05; ^#p < 0.01

ISSN: 1477-3155