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Table 3 Effects of rGO on biochemical parameters of hepatic and renal function

From: Reduced graphene oxide: nanotoxicological profile in rats

 

Unit

Control

rGO 15 min

rGO 1 h

rGO 3 h

rGO 7 days

ALT

U/L

44 ± 3.5

56 ± 3.9

54 ± 0.5

44 ± 3.2

48 ± 2.3

AST

U/L

148 ± 9.9

177 ± 8.4

152 ± 7.5

156 ± 9.5

151 ± 6.6

BUN

mg/dL

48 ± 2.2#

57 ± 3.2*,

45 ± 3.3*

35 ± 0.7#,

48 ± 1.8

Creatinine

mg/dL

0.31 ± 0.003

0.35 ± 0.017

0.29 ± 0.021

0.30 ± 0.017

0.34 ± 0.020

  1. Values are mean ± SEM of 3–5 animals in each group. The same symbol in each column indicates a significant difference between groups
  2. One-way ANOVA, Bonferroni post hoc test
  3. ALT alanine aminotransferase; AST aspartate aminotransferase; BUN blood urea nitrogen
  4. #,* p < 0.05; p < 0.001