Selective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node

Table 1 Physicochemical properties of PGA-PEG NCs

Physicochemical properties				EE [%]^b		Stability^d		Morphology^g
PGA-PEG NCs	Size [nm]	P.I^a	ζ Potential [mV]	DiD	DCX^c	Storage^e	Cell media^f	Morphology^g
Blank	116 ± 5	0.1	−29 ± 5	–	–	Yes	Yes
DiD-loaded	112 ± 12	0.1	−38 ± 2	56 ± 3	–	Yes	Yes	100 nm
DiD-DCX-loaded	109 ± 13	0.2	−39 ± 1	52 ± 1	48 ± 8	Yes	Yes	100 nm

Values are given as mean ± S.D, n = 3
^a PI polydispersity index, ^b EE encapsulation Efficiency, ^c DCX docetaxel, ^d Yes stands for stable nanocapsules at the conditions of study, ^e 4 ºC during 7 months, ^f 37 °C for 4 h in cell culture medium, ^g transmission electron microscopy micrograph

ISSN: 1477-3155