Fig. 1
From: Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting
a Schematic representation of self-auto-aggregation process leading to insoluble amyloid fibrils formation. b Strategy for specific amyloid protein targeting using AGuIX grafted with a selected peptide of Aβ. The nanoparticles are supposed to target the end of Aβ fibrils (represented in green) by the selected and grafted peptide, but not to amyloid fibrils of transthyretin (represented in yellow). c Transmission electronic microscopy pictures of Aβ amyloid fibrils after 7 days of incubation and (d) of transthyretin amyloid fibrils formed with V30M mutated protein, at 20 days of incubation