Fig. 5
From: Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting
Interaction of functionalized nanoparticles for Aβ(1–42) fibrils or V30M-TTR fibrils assessed by SPR experiments. a Remaining signal of AGuIX@PEG, AGuIX@PEG@Cy5.5, AGuIX@PEG@LPFFD@Cy5.5 and AGuIX@PEG@KLVFF@Cy5.5 at 2.5 mM in Gd3+ on Aβ(1–42) fibrils. The R.U. were measured 141 s after the end of the analyte injection. b, c The sensorgrams (colored curves) obtained for AGuIX@PEG@LPFFD@Cy5.5 (b) and for AGuIX@PEG@KLVFF@Cy5.5 (c) on Aβ(1–42) fibrils were fitted thanks to the Biaevaluation® software with the Langmuir 1:1 model (black curves). c Remaining signal of AGuIX@PEG@LPFFD@Cy5.5 (plain curves) and AGuIX@PEG@KLVFF@Cy5.5 (dashed curves) on Aβ(1–42) fibrils (blue) and V30M-TTR fibrils (red). The R.U. values plotted on the graph correspond to the measures at the time-point 141 s after the end of nanoparticles injection