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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles: assessment of biocompatibility and potential applications

Fig. 4

Transmission electron microscopy micrographs of labeled MSC. a Unlabeled MSC (control). b γ-Fe2O3-DMSA labeled MSC (80 µg/mL); the white arrows point some of the uptaken nanoparticles. c MSC labeled with Au-DMSA (90 µg/mL); the white arrowheads point some of the uptaken nanoparticles. d Cells exposed to Au-DMSA for 24 h presented myelin figures (black arrows) and e more electron-lucent structures (white arrows) compared to unlabeled cells. f In turn, after 24 h of exposure toγ-Fe2O3-DMSA, MSC presented signs of mitochondrial toxicity: mitochondria full of nanoparticles are swollen and degenerated (black arrows), as compared to organelles without them (white arrows). g These cells also presented some myelin figures (black arrows). h Lastly, γ-Fe2O3-DMSA nanoparticles were stored in vesicles (white arrows). Nu nucleus, M mitochondria, RER rough endoplasmic reticulum, L lipid

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