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Fig. 9 | Journal of Nanobiotechnology

Fig. 9

From: Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles: assessment of biocompatibility and potential applications

Fig. 9

γ-Fe2O3-DMSA as a potential agent for MSC magnetic targeting. a–d Magnetic responsiveness test in vitro. a, b γ-Fe2O3-DMSA labeled cells were seeded in culture plates with a fixed plastic piece (a) or a circular magnet (b). The region in orange corresponds to the site where the materials were fixed. c, d The culture plates were examined by light microscopy in order to demonstrate the difference in amount of cells present in regions highlighted in red. e Iron measurement by colorimetric dosage of Prussian blue. Data refer to the mean ± SD from the mass of iron present in lungs, divided by lung’s weight. f–h Histological analysis of MSC retention in silicotic mice lungs. The slides were stained with Prussian Blue technique and contrasted with neutral red, evidencing iron from the γ-Fe2O3-DMSA in blue. f Healthy animal treated with saline g Animals treated with γ-Fe2O3-DMSA labeled MSC without external magnets h Animal treated with labeled MSC and with external magnets

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