Fig. 6From: Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigenIncreased survival of ZNP/ZBP-ScaA immunized mice. Mice (n = 5/group) were immunized with ZNP, ZBP-ScaA, ZNP/ScaA, ZNP/ZBP-ScaA, and Alum/ZBP-ScaA three times at 2 weeks interval. One week after last immunization, mice were challenged with 100 × LD50 of O. tsutsugamushi. Their survival was monitored until all the surviving mice recovered from the disease. *p < 0.05; **p < 0.01Back to article page