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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer

Fig. 4

Deshielding effect. a The CAN-Mag@PNPs-tPApep1Lac NPs bind to the receptors on the tumor cells. b The CAN-Mag@PNPs-PEG-REGAcp-PEG/tPA-pep1Lac NPs are hindered to interact with the tumor cells due to the protective outer PEG-REGAcp-PEG shell. c The CAN-Mag@PNPs-PEG-REGAcp-PEG/tPA-pep1Lac NP exposed to activated MMP-9 release the outer shell and consequently the now accessible t-PApep1lac vectors are able to bind to tumor cells. Flow cytometry analysis was carried out as described in the “Methods” section. The number in the lower right corner depicts the percentage of NP-labeled cells

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Journal of Nanobiotechnology

ISSN: 1477-3155

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