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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer

Fig. 6

Evidence for uptake of vectorized NPs containing Fe2O3 (maghemite) in pancreatic tumors in mice shown as Prussian blue staining. Post MRI the animals were sacrificed and tumors and organs of interest were excised for subsequent analyses of FFPE-tissue sections for Fe-deposition (Prussian blue). Top Orthotopic (ortho.) tumor and subcutaneous (s.c.) tumor slices from a mouse ~ 1.5 h post injection of CAN-Mag@PNPs-PEG-REGAcp-PEG/tPA-pep1Lac (+NP). Bottom Ortho. and s.c. tumor slices from an untreated control mouse (−NP). 400 × magnification; arrows indicate some nanoparticle deposition areas (blue spots)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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