Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer

Table 3 Characterization of nanosystems

Nanosystem	Diameter [nm]	PDI	ζ-potential [mV]	Iron [mg/ml]	Dry matter [mg/ml]	tPApep1_lac [µM]
CAN-Mag-Chitosan-tPApep1_Lac PEG 2 kDa	191.6 ± 1.5	0.44 ± 0.03	34.2	0.45	2.74	38.4
CAN-Mag-Chitosan-tPApep1_Lac PEG 2&5 kDa	266 ± 0.5	0.46 ± 0.03	31.3	0.45	3.8	60.1
CAN-Mag-Chitosan-tPApep1_Lac PEG 5 kDa	156 ± 2	0.429 ± 0.02	21.4	0.48	8.8	37.4
CAN-Mag@PNPs-tPApep1_Lac	125.4 ± 1.8	0.133 ± 0.012	−15.4	0.636	6.0	12.9
CAN-Mag@PNPs-PEG-REGAcp-PEG	118.6 ± 1.2	0.140 ± 0.004	−18.4	0.50	5.9	–
CAN-Mag@PNPs-PEG-REGAcp-PEG/tPApep1_Lac	114.7 ± 2.9	0.196 ± 0.004	−5.8	0.641	6.6	31.7

ISSN: 1477-3155