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Table 5 Representative iron-distribution in subcellular fractions after 6 h NPs (500 µg Fe) treatment of Su.86.86 cells (2 × 106 cells in 10 cm culture dish)

From: Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer

Analyte

No NP Fe [ng/ml]

No-vect. NPa Fe [µg]

% of total Fe

Vector. NPb Fe [µg]

% of total Fe

Culture media

<5

175.9

39.3

13.86

0.9

Wash buffer

<5

48.23

10.8

18.73

4.2

Cytosol

9.55

1.18

0.3

1.41

0.3

Membrane

16.8

5.07

1.1

395.6

88.1

Nuclear

<5

11.51

2.6

18.2

4.1

Cytoskeleton

5.04

205.90

45.9

11.45

2.6

  1. aCAN-Mag-Chitosan PEG 2 and 5 kDa
  2. bCAN-Mag-Chitosan–tPApep1Lac PEG 2 and 5 kDa
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Journal of Nanobiotechnology

ISSN: 1477-3155

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