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Table 6 ROIs voxels quotients (entity/muscle) and signal intensities loss for organs of interest after administration of non-targeted and targeted NPs

From: Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer

Particle

Entity

SImean (entity)/SImean (muscle)

Signal loss (1 − post/pre)

Pre (t = 0 min)

Post (t = 5 min)

CAN-Mag@PNPs

Muscle a

232

243

−4.74

Tumor sc.

3.11

3.21

−3.22

Tumor ot.

3.43

3.33

2.92

Liver

1.91

0.57

70.16

Kidney

3.06

3.25

−6.21

CAN-Mag@PNPs-tPA-pep1Lac

Muscle a

249

196

21.29

Tumor sc.

3.52

3.21

8.81

Tumor ot.

3.18

2.41

24.21

Liver

1.33

0.38

71.48

Kidney

2.54

1.69

33.46

CAN-Mag@PNPs-PEG-REGAcp-PEG/tPA-pep1Lac

Muscle a

243

256

−5.36

Tumor sc.

3.89

3.42

12.08

Tumor ot.

4.57

3.85

15.75

Liver

1.81

0.37

79.56

Kidney

4.38

2.76

36.99

  1. aValues are mean signal intensities not normalized to muscle