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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds

Fig. 1

Synthesis and characterization of miR-122-InP QDs-loaded graphene oxide composites. A a Low magnification image of InP QDs (Scale bar 20 nm). A b HRTEM image of InP QDs (Scale bar 3 nm). B a TEM image of miR-122-InP QDs-loaded graphene oxide composites (Scale bar 50 nm). B b TEM image of GPMQN (Scale bar 50 nm). C Size distribution of GPMQN in the culture medium characterized by dynamic light scattering. D Calculating quantum yields of GPMQNs (a) and compare with bare QDs (b); (c) Histograms of quantum yields of GPMQNs (a) and compare with bare QDs (b). E Verified function of miR-122 by GSH through AO fluorescence assay; 1 AO + miR-122, 2 AO + GPMQN, 3 AO + GPMQNs + 0.2 mM GSH, 4 AO + GPMQNs + 1 mM GSH, 5 AO + GPMQN + 5 mM GSH, 6 AO + GPMQN + 10 mM GSH. F Confirmed function of miR-122 release by GSH through agarose gel electrophoresis assay; 1 AO + miR-122, 2 AO + GPMQN, 3 AO + GPMQN + 0.2 mM GSH, 4 AO + GPMQN + 1 mM GSH, 5 AO + GPMQN + 5 mM GSH, 6 AO + GPMQN + 10 mM GSH. G Emission spectrum of GPMQN, excitation wavelength at 650 nm. H Quantification of P-gp antibody remaining in solution; 1 0 h, 2 1 h, 3 4 h, 4 8 h, 5 12 h exposure to graphene oxide (*P < 0.05 compared to the control group)

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