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Table 1 Pharmacokinetic parameters and bioavailability of oral formulations

From: Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy

 

T1/2(α) (h)

T1/2(β) (h)

Tmax (h)

Cmax (ng/ml)

AUC(0−∞) (ng h/ml)

Scu

0.405 ± 0.055

1.885 ± 0.105

1.235 ± 0.025

128.533 ± 85.467

6.419 ± 1.051

Chit-DC-Scu

1.446 ± 0.136

2.434 ± 0.154

2.375 ± 0.095

196.653 ± 45.239*

13.034 ± 1.135*

Chit-DC-VB12-Scu

2.529 ± 0.064

2.720 ± 0.250

3.776 ± 0.198

213.666 ± 81.786*

22.096 ± 2.064*

  1. Each data point represents mean ± SD, n = 6 for plasma pharmacokinetic parameters
  2. AUC is for scutellarin in plasma
  3. * Significantly different (P < 0.05) from Scu group
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Journal of Nanobiotechnology

ISSN: 1477-3155

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