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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles: a prerequisite for in vivo tracking of MSCs

Fig. 4

Effect of Au NP exposure on MSC in vitro proliferation and migration. The proliferation potential P upon exposure to Au NPs was normalized to that of untreated cells (cNP = 0 nM) and those treated with a mitosis inhibitor. Proliferation of MSCs exposed to cNP = 50 nM (24 h exposure) was significantly reduced (p < 0.05). The migration capacity after Au NP labeling is displayed as the ratio of the number of migrated cells Nmig divided by the total cell number, which is the sum of non-migrated cells Nnon–mig and migrated cells: Ntot = Nmig + Nnon–mig. The results were normalized to that of untreated cells (cNP = 0 nM) and to the negative control, where serum free media was used in the lower compartment. Migration of MSCs exposed to cNP = 25 nM was significantly reduced (p < 0.001)

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