Fig. 5
Induction of specific anti-DENV3 humoral responses in immunized mice. Animals were immunized with either MWNT-DENV3E, MWNT, DENV3E or PBS plus adjuvant using a prime-boos-boost regimen. 14 days after the last boost animals were bled and the generation of anti-DNEV3 was assayed. a Immunization with MWNT-DENV3E and DENV3E induced similarly high anti-DENV3E IgG responses, with detectable titers of up to the 1/51200 serum dilution. b Mice immunized with MWNT-DENV3E showed the higher PRNT50 titers (1/80), while groups immunized with DENV3E, MWNT and saline showed only background levels of 1/20. Dotted line represents the 50% neutralization rate cut-off