Fig. 18
Deposition characterization of aerosolised nano-sized and micron-sized particles. a Average mass deposition (ng/cm2) of particles quantified using a quartz crystal microbalance (QCM) following nebulisation of low (1 mg), medium (6 mg) and high (11 mg) particle doses using a dry powder insufflator. Data are presented as the mean ± standard error of the mean. b Transmission electron micrographs of aerosolized nano- (left) and microparticles (right), indicating, in a qualitative manner, the heterogeneity of the particle deposition for each particle-size. Images also show a representative overview of the particle morphology following the aerosolisation process