Fig. 3

a The cellular uptake of AG-P-SS-P/Rh123 with 0 and 10 mM GSH by A549/ADR cells using laser scanning confocal microscopy (×400). b1 CLSM images of A549/ADR cells after 30 min of incubation with P-SS-P/Rh123 (non-targeted) and AG-P-SS-P/Rh123 (targeted) (×200). Free AG (10 mM) was used to block GLUT1 binding before adding AG-P-SS-P/Rh123. b2 Fluorescence intensity of Rh123-loaded P-SS-P (non-targeted) and AG-P-SS-P (targeted) in A549/ADR cells. Quantitative analysis was performed with ImageJ. *P < 0.05, compared with 10 mM GSH. *P < 0.05, compared with AG-P-SS-P/Rh123 nanomicelles, respectively. (1) Image of CLSM; (2) Fluorescence intensity of image