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Table 2 Acute lethal results by single oral administration in mice (n = 10)

From: Selenium nanoparticles-loaded chitosan/citrate complex and its protection against oxidative stress in d-galactose-induced aging mice

Sample

Se content (mg g−1)

ICR mice

KM mice

LD50 (g kg−1 bw)

LD50(Se) (mg Se kg−1 bw)

LD50 (g kg−1 bw)

LD50(Se) (mg Se kg−1 bw)

Sodium selenite

456.7

7.4 × 10−3 (5.3–10.3) × 10−3a

3.4 (2.4–4.7)b

1.92 × 10−2 (1.62–2.27) × 10−2a

8.8 (7.4–10.4)b

Blank-C/C

–

> 15

–

> 20

–

SeNPs-C/C

10.5

3.72 (2.57–5.40)a

39.1 (27.0–56.7)b

3.54 (2.97–4.23)a

37.2 (31.2–44.4)b

  1. LD50 = median lethal dose; LD50(Se) = LD50 × Se content
  2. aThe LD50 of 95% confidence interval
  3. bThe LD50(Se) of 95% confidence interval