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Table 1 Anthropometry of mice after 9 weeks of HFD and AuNP treatments

From: Gold nanoparticles improve metabolic profile of mice fed a high-fat diet

  Chow-C HFD-C HFD-LAu HFD-HAu
Body weight initial (g) 20.2 ± 0.3 20.2 ± 0.3 20.3 ± 0.2 20.2 ± 0.3
Body weight final (g) 27.7 ± 0.3 37.5 ± 1.2* 34.5 ± 0.8* 35.8 ± 0.6*
Energy intake (kJ/day) 44.9 ± 0.6 48.4 ± 1.4 50.5 ± 1.4* 52.3 ± 1.4*
Heart (g) 0.135 ± 0.002 0.145 ± 0.004 0.138 ± 0.004 0.141 ± 0.004
Heart (%) 0.49 ± 0.01 0.40 ± 0.01* 0.39 ± 0.02* 0.40 ± 0.01*
Kidney (g) 0.165 ± 0.004 0.192 ± 0.005* 0.179 ± 0.004* 0.188 ± 0.005*
Kidney (%) 0.59 ± 0.01 0.51 ± 0.02* 0.49 ± 0.02* 0.53 ± 0.02*
Liver (g) 1.34 ± 0.03 1.86 ± 0.12* 1.49 ± 0.03* 1.54 ± 0.04*
Liver (%) 4.86 ± 0.08 5.03 ± 0.12 4.27 ± 0.07* 4.30 ± 0.10*
Retroperitoneal fat (g) 0.097 ± 0.006 0.761 ± 0.054* 0.652 ± 0.044* 0.616 ± 0.048*
Retroperitoneal fat (%) 0.35 ± 0.02 2.01 ± 0.10* 1.86 ± 0.11* 1.77 ± 0.09*
Mesenteric fat (g) 0.372 ± 0.018 0.939 ± 0.075* 0.741 ± 0.060* 0.691 ± 0.029*
Mesenteric fat (%) 1.35 ± 0.06 2.46 ± 0.14* 2.07 ± 0.28* 1.97 ± 0.07*
Epididymal fat (g) 0.405 ± 0.013 2.029 ± 0.19* 1.77 ± 0.12* 1.80 ± 0.09*
Epididymal fat (%) 1.43 ± 0.06 5.38 ± 0.35* 5.07 ± 0.14* 4.98 ± 0.19*
Plasma insulin (ng/ml) 1.05 ± 0.12 1.09 ± 0.12 1.44 ± 0.21* 1.11 ± 0.05
Plasma NEFA (nm) 2.54 ± 0.16 4.51 ± 0.54* 2.9 ± 0.24 3.14 ± 0.35
Plasma cholesterol (mm) 6.24 ± 0.31 11.14 ± 0.36* 9.40 ± 0.29* 9.46 ± 0.41*
Plasma triglyceride (mm) 0.75 ± 0.05 0.86 ± 0.05 0.67 ± 0.04 0.69 ± 0.05
Liver triglyceride (mm/mg) 0.023 ± 0.005 0.124 ± 0.019* 0.139 ± 0.007* 0.145 ± 0.010*
Plasma ALT (U/L) 17.3 ± 6.2 55.9 ± 13* 25.5 ± 6.9 26.3 ± 2.4
Plasma AST (U/L) 6.33 ± 2.16 31.4 ± 7.1* 16.9 ± 3.9 12.1 ± 2.2
  1. Data are expressed in mean ± S.E.M. Data were analyzed using one-way ANOVA, followed by post hoc Bonferroni tests
  2. n = 20/group for anthropometry markers; n = 8/group for plasma insulin, NEFA, cholesterol, triglyceride, and liver triglyceride concentrations; n = 6/group for plasma ALT and AST concentration
  3. P < 0.05 vs. Chow-C;  P < 0.05 vs. HFD-C