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Table 1 Anthropometry of mice after 9 weeks of HFD and AuNP treatments

From: Gold nanoparticles improve metabolic profile of mice fed a high-fat diet

 

Chow-C

HFD-C

HFD-LAu

HFD-HAu

Body weight initial (g)

20.2 ± 0.3

20.2 ± 0.3

20.3 ± 0.2

20.2 ± 0.3

Body weight final (g)

27.7 ± 0.3

37.5 ± 1.2*

34.5 ± 0.8*†

35.8 ± 0.6*

Energy intake (kJ/day)

44.9 ± 0.6

48.4 ± 1.4

50.5 ± 1.4*

52.3 ± 1.4*†

Heart (g)

0.135 ± 0.002

0.145 ± 0.004

0.138 ± 0.004

0.141 ± 0.004

Heart (%)

0.49 ± 0.01

0.40 ± 0.01*

0.39 ± 0.02*

0.40 ± 0.01*

Kidney (g)

0.165 ± 0.004

0.192 ± 0.005*

0.179 ± 0.004*

0.188 ± 0.005*

Kidney (%)

0.59 ± 0.01

0.51 ± 0.02*

0.49 ± 0.02*

0.53 ± 0.02*

Liver (g)

1.34 ± 0.03

1.86 ± 0.12*

1.49 ± 0.03*†

1.54 ± 0.04*†

Liver (%)

4.86 ± 0.08

5.03 ± 0.12

4.27 ± 0.07*†

4.30 ± 0.10*†

Retroperitoneal fat (g)

0.097 ± 0.006

0.761 ± 0.054*

0.652 ± 0.044*

0.616 ± 0.048*†

Retroperitoneal fat (%)

0.35 ± 0.02

2.01 ± 0.10*

1.86 ± 0.11*

1.77 ± 0.09*†

Mesenteric fat (g)

0.372 ± 0.018

0.939 ± 0.075*

0.741 ± 0.060*†

0.691 ± 0.029*†

Mesenteric fat (%)

1.35 ± 0.06

2.46 ± 0.14*

2.07 ± 0.28*†

1.97 ± 0.07*†

Epididymal fat (g)

0.405 ± 0.013

2.029 ± 0.19*

1.77 ± 0.12*

1.80 ± 0.09*

Epididymal fat (%)

1.43 ± 0.06

5.38 ± 0.35*

5.07 ± 0.14*

4.98 ± 0.19*

Plasma insulin (ng/ml)

1.05 ± 0.12

1.09 ± 0.12

1.44 ± 0.21*†

1.11 ± 0.05

Plasma NEFA (nm)

2.54 ± 0.16

4.51 ± 0.54*

2.9 ± 0.24†

3.14 ± 0.35†

Plasma cholesterol (mm)

6.24 ± 0.31

11.14 ± 0.36*

9.40 ± 0.29*†

9.46 ± 0.41*†

Plasma triglyceride (mm)

0.75 ± 0.05

0.86 ± 0.05

0.67 ± 0.04†

0.69 ± 0.05†

Liver triglyceride (mm/mg)

0.023 ± 0.005

0.124 ± 0.019*

0.139 ± 0.007*

0.145 ± 0.010*

Plasma ALT (U/L)

17.3 ± 6.2

55.9 ± 13*

25.5 ± 6.9†

26.3 ± 2.4†

Plasma AST (U/L)

6.33 ± 2.16

31.4 ± 7.1*

16.9 ± 3.9†

12.1 ± 2.2†

  1. Data are expressed in mean ± S.E.M. Data were analyzed using one-way ANOVA, followed by post hoc Bonferroni tests
  2. n = 20/group for anthropometry markers; n = 8/group for plasma insulin, NEFA, cholesterol, triglyceride, and liver triglyceride concentrations; n = 6/group for plasma ALT and AST concentration
  3. * P < 0.05 vs. Chow-C; † P < 0.05 vs. HFD-C