Fig. 7

Quantitative analysis of LPMSNPs across the in vitro BBB model. a The fluorescence intensity of FTIC-labeled LPMSNPs in upper Transwell chamber at 0 and 24 h. Significant decrease in fluorescence intensity was observed after 24 h suggesting transport of MSNPs across the BBB. b The concentration of RSV in lower culture medium released from different NPs groups in presence and absence of PMA stimulation. Higher RSV release was observed in all peptide bound LPMSNPs upon PMA stimulation. The minimum RSV release was observed from PMSNPs without peptide. *p < 0.05 vs 0 h; ^#p < 0.05 vs L1:1 at 24 h