Table 3 Gene regulation in liver and kidney in response to 90 days CeO2 and BaSO4 exposure
Array | Gene | CeO2 | BaSO4 | |||
|---|---|---|---|---|---|---|
Liver | Kidney | Liver | Kidney | |||
Inflammatory cytokines and receptors | Ccr2 | Chemokine (C–C motif) receptor 2 |
| Â |
| Â |
Cx3cl1 | Chemokine (C–X3–C motif) ligand 1 |
| Â | Â | Â | |
Cxcl12 | Chemokine (C–X–C motif) ligand 12 |
| Â | Â | Â | |
Cxcr2 | Chemokine (C–X–C motif) receptor 2 |
| Â | Â | Â | |
Cxcr3 | Chemokine (C–X–C motif) receptor 3 |
| Â |
| Â | |
Il2rg | Interleukin 2 receptor, gamma |
| Â | Â | Â | |
Osm | Oncostatin M |
|
| Â | Â | |
Ccl2 | Chemokine (C–C motif) ligand 2 |  |  |  |
| |
Ccl9 | Chemokine (C–C motif) ligand 9 |  |
| Â |
| |
Cxcr5 | Chemokine (C–X–C motif) receptor 5 |  |
| Â | Â | |
Spp1 | Secreted phosphoprotein 1 | Â |
| Â | Â | |
Oxidative stress | Gpx2 | Glutathione peroxidase 2 |
|
| Â | Â |
Lpo | Lactoperoxidase |
| Â |
| Â | |
Ncf2 | Neutrophil cytosolic factor 2 |
|
| Â | Â | |
Scd1 | Stearoyl-Coenzyme A desaturase 1 |
|
|
|
| |
Alb | Albumin | Â |
| Â |
| |
Epx | Eosinophil peroxidase | Â |
| Â | Â | |
Gclc | Glutamate-cysteine ligase, catalytic SU | Â |
| Â | Â | |
Gclm | Glutamate cysteine ligase, modifier SU | Â |
| Â | Â | |
Hba1 | Hemoglobin alpha, adult chain 2 | Â |
| Â | Â | |
Mpo | Myeloperoxidase | Â |
| Â | Â | |
Ngb | Neuroglobin | Â |
| Â |
| |
Txnip | Thioredoxin interacting protein | Â |
| Â |
| |
DNA repair | Lig4 | Ligase IV, DNA, ATP-dependent |
|
|
| Â |
Smug1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1 |
| Â | Â | Â | |
Xrcc2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | Â | Â |
| Â | |
Brca1 | Breast cancer 1 | Â |
| Â | Â | |
Total | 27 | Â | 13 | 17 | 6 | 6 |
-
upregulation;
downregulation;
up- or downregulation (differences between dose groups); cut-off: FR ≤ − 2.0 or ≥ 2.0