Table 1 Effect of the non-ionic surfactant Tween 60: cholesterol with various molar ratios on entrapment efficiency (EE %), size and % release (R) in CUR/PTX loaded Niosomes
Code | Mole Tween 60 (%) | Mole cholesterol (%) | EE (%) | R (%) | Size (nm) | PDI | Zeta potential (mV) |
|---|---|---|---|---|---|---|---|
F1 | 90 | 10 | EE % CUR = 52.24 ± 0.47 EE % PTX = 45.24 ± 0.12 | R % CUR = 75.26 ± 0.42 R % PTX = 65.14 ± 0.32 | Size CUR = 101.5 ± 0.12 Size PTX = 122.4 ± 0.46 | PDI CUR = 0.281 ± 0.056 PDI PTX = 0.261 ± 0.056 | Zeta CUR = − 20.34 ± 0.68 Zeta PTX = − 16.62 ± 0.47 |
F2 | 80 | 20 | EE % CUR = 66.12 ± 0.86 EE % PTX = 61.74 ± 0.36 | R % CUR = 69.11 ± 0.24 R % PTX = 56.12 ± 0.66 | Size CUR = 107.5 ± 0.31 Size PTX = 131.24 ± 0.31 | PDI CUR = 0.246 ± 0.12 PDI PTX = 0.236 ± 0.12 | Zeta CUR = − 22.41 ± 0.75 Zeta PTX = − 19.08 ± 0.36 |
F3 | 75 | 25 | EE % CUR = 81.24 ± 0.47 EE % PTX = 72.44 ± 0.63 | R % CUR = 57.26 ± 0.11 R % PTX = 47.24 ± 0.36 | Size CUR = 112.7 ± 0.64 Size PTX = 140.66 ± 0.72 | PDI CUR = 0.224 ± 0.087 PDI PTX = 0.214 ± 0.087 | Zeta CUR = − 21.38 ± 0.86 Zeta PTX = − 21.54 ± 0.44 |
F4 | 70 | 30 | EE % CUR = 85.42 ± 0.11 EE % PTX = 81.37 ± 0.21 | R % CUR = 46.11 ± 0.34 R % PTX = 39.22 ± 0.41 | Size CUR = 118.7 ± 0.56 Size PTX = 149.32 ± 0.65 | PDI CUR = 0.204 ± 0.062 PDI PTX = 0.194 ± 0.062 | Zeta CUR = − 21.45 ± 0.42 Zeta PTX = − 19.56 ± 0.27 |
F5 | 50 | 50 | EE % CUR = 71.24 ± 0.16 EE % PTX = 67.12 ± 0.47 | R % CUR = 54.12 ± 0.22 R % PTX = 45.14 ± 0.32 | Size CUR = 125.1 ± 0.44 Size PTX = 157.44 ± 0.66 | PDI CUR = 0.214 ± 0.013 PDI PTX = 0.208 ± 0.013 | Zeta CUR = − 24.16 ± 0.22 Zeta PTX = − 24.56 ± 0.42 |