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Table 2 Pharmacokinetic parameters for AMO-loaded KNPs in rats after oral administration (mean ± SD; n = 6)

From: Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release

Formulation Tmax (h) AUC0–12 h (µg h/mL) Cmax (µg/mL)
KNP-1 3.75 ± 0.12 18.28 ± 1.35 1.95 ± 0.01
KNP-2 3.02 ± 0.08 25.82 ± 1.09 3.12 ± 0.33
KNP-3 3.00 ± 0.10 24.05 ± 1.17 3.23 ± 0.29
KNP-4 2.33 ± 0.02 22.10 ± 0.28 3.02 ± 0.10
AMO 1.26 ± 0.04 18.90 ± 0.10 3.75 ± 0.11