Table 2 Pharmacokinetic parameters for AMO-loaded KNPs in rats after oral administration (mean ± SD; n = 6)
From: Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release
Formulation | Tmax (h) | AUC0–12 h (µg h/mL) | Cmax (µg/mL) |
|---|---|---|---|
KNP-1 | 3.75 ± 0.12 | 18.28 ± 1.35 | 1.95 ± 0.01 |
KNP-2 | 3.02 ± 0.08 | 25.82 ± 1.09 | 3.12 ± 0.33 |
KNP-3 | 3.00 ± 0.10 | 24.05 ± 1.17 | 3.23 ± 0.29 |
KNP-4 | 2.33 ± 0.02 | 22.10 ± 0.28 | 3.02 ± 0.10 |
AMO | 1.26 ± 0.04 | 18.90 ± 0.10 | 3.75 ± 0.11 |