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Table 3 Thermodynamic parameters for binding of keratins to MUC at different pH

From: Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release

Complexes

pH

K a (M−1)

∆H (kcal/mol)

∆G (kcal/mol)

− T∆S (kcal/mol)

n

KTN + PGM

4.5

(3.98 ± 1.82) × 105

− 2.41 ± 0.02

− 33.2 ± 0.13

30.8 ± 1.07

1.23 ± 0.02

KOS + PGM

4.5

(1.55 ± 0.71) × 104

− 4.25 ± 0.05

− 24.8 ± 0.20

20.6 ± 0.39

1.15 ± 0.03

KTN + PGM

7.4

(1.07 ± 0.12) × 104

− 3.47 ± 0.10

− 23.9 ± 0.16

20.4 ± 0.14

1.50 ± 0.01

KOS + PGM

7.4

(4.14 ± 1.15) × 103

− 61.1 ± 1.53

− 21.5 ± 1.01

− 39.6 ± 1.13

1.27 ± 0.02