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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Nanoparticles engineered to bind cellular motors for efficient delivery

Fig. 4

a Accumulation of Au@DynPro at the MTOC near the nucleus (N). b Progression of Au@DynPro towards the MTOC, or c nucleus and projections (arrows) in GFP-tubulin transfected cells. di Au@DynPro´s mobility was sensitive to microtubule-depolimerizing drugs. d, g Widespread cellular distribution of Au@DynPro before depolymerizing drug treatment, e Au@DynPro transport blockade and accumulation after 1 h drug incubation with 2.5 µM Nocodazole, and f mobility and dispersion recovery after washing. g Vero cells treated with 10 µM Au@DynPro and then h incubated for 1 h with 0.1 µM actin depolymerizing-drug LatrunculinA. This drug produced cell shrinkage because of actin cytoskeleton collapse that was not recovered after washing (i). However, Au@DynPro transport was still preserved within cells and projections. Scale bar: 10 µm

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