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Table 2 Values of the matrix of a factorial design of concentration parameters and measured responses

From: Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization

  c PLGA− PEG c MEM c PVA Zav (nm) PI ZP (mV) EE (%)
Coded level (mg/ml) Coded level (mg/ml) Coded level (mg/ml)
Factorial points
F1 − 1 10 − 1 3 − 1 2.5 270.0 ± 2.4 0.081 ± 0.002 − 13.4 ± 0.93 50.45
F2 1 30 − 1 3 − 1 2.5 450.1 ± 6.6 0.306 ± 0.022 − 8.27 ± 0.16 60.84
F3 − 1 10 1 9 − 1 2.5 230.1 ± 3.2 0.034 ± 0.026 − 2.95 ± 0.23 98.98
F4 1 30 1 9 − 1 2.5 369.3 ± 3.4 0.287 ± 0.028 − 3.33 ± 0.13 98.76
F5 − 1 10 − 1 3 1 7.5 324.4 ± 3.8 0.188 ± 0.009 − 9.79 ± 0.27 57.74
F6 1 30 − 1 3 1 7.5 287.8 ± 4.6 0.139 ± 0.029 − 7.84 ± 0.25 72.07
F7 − 1 10 1 9 1 7.5 177.9 ± 2.9 0.034 ± 0.030 − 3.81 ± 0.44 81.23
F8 1 30 1 9 1 7.5 223.4 ± 0.6 0.063 ± 0.007 − 3.88 ± 0.17 84.87
Axial points
F9 1.68 37 0 5 0 5 260.4 ± 1.6 0.102 ± 0.018 − 8.85 ± 0.53 66.08
F10 − 1.68 3 0 5 0 5 147.1 ± 0.7 0.032 ± 0.007 − 4.96 ± 0.17 69.52
F11 0 20 1.68 11 0 5 204.3 ± 2.5 0.081 ± 0.018 − 3.86 ± 0.27 52.84
F12 0 20 − 1.68 1 0 5 238.8 ± 0.7 0.077 ± 0.013 − 14.5 ± 0.45 55.33
F13 0 20 0 5 1.68 9.2 199.0 ± 2.1 0.071 ± 0.027 − 5.59 ± 0.19 57.27
F14 0 20 0 5 − 1.68 0.8 272.2 ± 2.1 0.103 ± 0.033 − 3.26 ± 0.19 65.65
Center points
F15 0 20 0 5 0 5 213.1 ± 0.4 0.023 ± 0.024 − 6.03 ± 0.27 72.61
F16 0 20 0 5 0 5 211.7 ± 0.3 0.034 ± 0.023 − 5.96 ± 0.16 40.92
  1. Italic values correspond to the optimized formulation of MEM loaded NPs