Table 2 Values of the matrix of a factorial design of concentration parameters and measured responses
c PLGA− PEG | c MEM | c PVA | Zav (nm) | PI | ZP (mV) | EE (%) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Coded level | (mg/ml) | Coded level | (mg/ml) | Coded level | (mg/ml) | |||||
Factorial points | ||||||||||
F1 | − 1 | 10 | − 1 | 3 | − 1 | 2.5 | 270.0 ± 2.4 | 0.081 ± 0.002 | − 13.4 ± 0.93 | 50.45 |
F2 | 1 | 30 | − 1 | 3 | − 1 | 2.5 | 450.1 ± 6.6 | 0.306 ± 0.022 | − 8.27 ± 0.16 | 60.84 |
F3 | − 1 | 10 | 1 | 9 | − 1 | 2.5 | 230.1 ± 3.2 | 0.034 ± 0.026 | − 2.95 ± 0.23 | 98.98 |
F4 | 1 | 30 | 1 | 9 | − 1 | 2.5 | 369.3 ± 3.4 | 0.287 ± 0.028 | − 3.33 ± 0.13 | 98.76 |
F5 | − 1 | 10 | − 1 | 3 | 1 | 7.5 | 324.4 ± 3.8 | 0.188 ± 0.009 | − 9.79 ± 0.27 | 57.74 |
F6 | 1 | 30 | − 1 | 3 | 1 | 7.5 | 287.8 ± 4.6 | 0.139 ± 0.029 | − 7.84 ± 0.25 | 72.07 |
F7 | − 1 | 10 | 1 | 9 | 1 | 7.5 | 177.9 ± 2.9 | 0.034 ± 0.030 | − 3.81 ± 0.44 | 81.23 |
F8 | 1 | 30 | 1 | 9 | 1 | 7.5 | 223.4 ± 0.6 | 0.063 ± 0.007 | − 3.88 ± 0.17 | 84.87 |
Axial points | ||||||||||
F9 | 1.68 | 37 | 0 | 5 | 0 | 5 | 260.4 ± 1.6 | 0.102 ± 0.018 | − 8.85 ± 0.53 | 66.08 |
F10 | − 1.68 | 3 | 0 | 5 | 0 | 5 | 147.1 ± 0.7 | 0.032 ± 0.007 | − 4.96 ± 0.17 | 69.52 |
F11 | 0 | 20 | 1.68 | 11 | 0 | 5 | 204.3 ± 2.5 | 0.081 ± 0.018 | − 3.86 ± 0.27 | 52.84 |
F12 | 0 | 20 | − 1.68 | 1 | 0 | 5 | 238.8 ± 0.7 | 0.077 ± 0.013 | − 14.5 ± 0.45 | 55.33 |
F13 | 0 | 20 | 0 | 5 | 1.68 | 9.2 | 199.0 ± 2.1 | 0.071 ± 0.027 | − 5.59 ± 0.19 | 57.27 |
F14 | 0 | 20 | 0 | 5 | − 1.68 | 0.8 | 272.2 ± 2.1 | 0.103 ± 0.033 | − 3.26 ± 0.19 | 65.65 |
Center points | ||||||||||
F15 | 0 | 20 | 0 | 5 | 0 | 5 | 213.1 ± 0.4 | 0.023 ± 0.024 | − 6.03 ± 0.27 | 72.61 |
F16 | 0 | 20 | 0 | 5 | 0 | 5 | 211.7 ± 0.3 | 0.034 ± 0.023 | − 5.96 ± 0.16 | 40.92 |