Fig. 6

CLSM images of human endothelial cells exposed to HA particles (10 and 50 μg/mL) and stained for F-Actin cytoskeleton. On control cells, the cytoskeleton was organized in a network of well-defined and filamentous stress fibres; HAp1 had little effect in this behaviour, whereas HAp2 caused dose-dependent disruption in the cytoskeleton that was shown by diffuse F-actin organization, less stress fibre formation and F-actin condensation (particularly with 50 μg/mL)