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Fig. 12 | Journal of Nanobiotechnology

Fig. 12

From: Oligohistidine and targeting peptide functionalized TAT-NLS for enhancing cellular uptake and promoting angiogenesis in vivo

Fig. 12

Cellular uptake analysis of various REDV-TAT-NLS-Hn/Cy5-oligonucleotide complexes after 4 h transfection (1), percentages of cellular uptake and mean fluorescence intensity (MFI) measured by flow cytometry (2), mean fluorescence intensity of HUVECs and HUASMCs transfected by REDV-TAT-NLS-H12/Cy5-oligonucleotide complexes (3), and CLSM images of intracellular trafficking of various REDV-TAT-NLS-Hn/Cy5-oligonucleotide complexes (4). (A) REDV-TAT-NLS-H0/Cy5-oligonucleotide complexes treated group, (B) REDV-TAT-NLS-H4/Cy5-oligonucleotide complexes treated group, (C) REDV-TAT-NLS-H8/Cy5-oligonucleotide complexes treated group, (D) REDV-TAT-NLS-H12/Cy5-oligonucleotide complexes treated group, (E) Cy5-oligonucleotide treated group as a control group (mean ± SD, n = 3, *P < 0.05 vs. control group)

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