Fig. 7

Biodistribution of APTMS conjugated (N2-APTMS), and folic acid-functionalized Gd₂O₃:Eu³⁺ nanoparticles (N3-FA) in breast cancer tumor xenografts. a Confocal microscopy images of different tumor sections showing biodistribution of N2-APTMS and N3-FA at 2 h after i.v. injection, b mean fluorescent intensity as a function of N3-FA accumulation in tumors of MDA-MB-231 and T-47D tumor-bearing mice. **P < 0.01 vs. T-47D tumors with N3-FA treatment using 1-way ANOVA with a Bonferroni post-test, c biodistribution of N2-APTMS and N3-FA in different organs of tumor-bearing mice, analyzed using confocal microscopy images 2 h after i.v. injection, d mean fluorescent intensity as a function of N3-FA accumulation in different organs of MDA-MB-231 and T-47D tumor-bearing mice. *P < 0.05; **P < 0.01 vs. kidney of MDA-MB-231 tumor-bearing mice treated with N3-FA using 2-way ANOVA with a Bonferroni post-test. Error bars represent the SEM of fluorescent intensity of 3 different tissues. Scale bar = 50 µm