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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells

Fig. 8

Effect of drug or P4-PDC pre-incubation of cytotoxic activity. Free drugs, free P4-PDCs or P4-PDC-PEG-AuNPs were incubated for 24,48 or 72 h at 37 °C and then added to A20 cells for a further 72 h after which cell growth was assessed using the XTT assay: optical density (OD) was measured at 480 and 680 nm—the latter is the background absorbance. The difference between the 480 and 680 nm measurement was used to calculate the % growth inhibition (GI) in test wells compared with control cells exposed to medium alone. The results shown for each concentration point represent the mean ± standard error for two independent experiments each conducted in (n = 3). Only the results for fresh P4-PDC versus pre-incubated P4-PDC-PEG-AuNPs are shown as pre-incubation of free drugs or free PDC4 abolished their cytotoxic activity by more than 93%

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