Fig. 3From: Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezersa Results of single DNA molecule overwinding experiments with stepwise increased MTX concentration at a preset force of 0.2 pN; b plot of the change of the rotation number ΔR with corresponding elongation of the DNA contour length ΔL. The slope (linear approximation, solid line) allows estimating the unwinding angle per intercalated MTX moleculeBack to article page