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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Chiral polymer modified nanoparticles selectively induce autophagy of cancer cells for tumor ablation

Fig. 4

The possible chirality-dependent mechanisms of the PAV-AuNPs on autophagy-inducing activity. a l- and d-PAV-AuNPs reduced lysosome stability in MDA-MB-231 cells. b Generation of ROS in MDA-MB-231 cells exposed to l- or d-PAV-AuNPs with an Au concentration of 100 µg/mL in the presence or absence of antioxidants (NAC), respectively. ROS up is regarded as the positive control. The mean fluorescence intensity (MFI) is quantified using FCM. c The level of LC3-II in MDA-MB-231 and treated without (Control) or with d-PAV-AuNPs in the presence or absence of NAC for 24 h is determined by western-blotting, GAPDH served as loading control. d Cellular uptake of l(d)-PAV-AuNPs. Quantification of the Au amount per 104 cells is presented as the mean ± standard deviation (n = 4). * and ** present p < 0.05 and p < 0.01, respectively

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