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Table 1 Physicochemical characteristics of PSNPs

From: Impact of nanoparticle surface functionalization on the protein corona and cellular adhesion, uptake and transport

PSNP Hydrodynamic diameter (dh) (nm) of PSNPs in Water and DMEM+ Simulated fraction of nominal dose deposited (ISDD modelling) Zeta-potential (mV) of PSNPs in DMEM+
Water (t = 0) DMEM+ (t = 0 min) DMEM+ (t = 30 min) DMEM+ (t = 24 h) DMEM+ (t = 30 min) DMEM+ (t = 24 h) DMEM+ (t = 0) DMEM+ (t = 24 h)
50 nm (-SM) 52.9 ± 0.2 78.1 ± 11.6 83.3 ± 13.5 55.9 ± 9.6 0.011 0.092 − 13.3 ± 1.5 − 11.9 ± 0.9
50 nm (-CM) 43.9 ± 6.4 61.5 ± 12.4 58.3 ± 8.4 53.7 ± 20.4 0.013 0.093 − 10.2 ± 0.8 − 10.2 ± 1.1
50 nm (-CP) 52.8 ± 9 111.6 ± 23.1a 96.2 ± 20.8a 93.7 ± 19.2a 0.010 0.071 − 8.8 ± 1.5 − 9.2 ± 0.9
200 nm (-CP) 208.3 ± 7.4 267.3 ± 9.7a 238.4 ± 22.9 305 ± 9abc 0.007 0.045 − 11.1 ± 2.3 − 10.4 ± 0.6
  1. Hydrodynamic diameters (nm) of PSNPs in water and DMEM+ (n = 3) and the zeta-potential (mV) in DMEM+ (n = 3)
  2. (-SM) PSNPs functionalized with sulfone from Magsphere; (-CM) PSNPs functionalized with carboxyl from Magsphere, (-CP) PSNPs functionalized with carboxyl from Polysciences
  3. aSignificance difference versus water (0 min)
  4. bSignificance difference versus DMEM+ (0 min)
  5. cSignificance difference versus DMEM+ (30 min)